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姓名：李勇

出生年月：1968年1月

基本情況：昆明醫(yī)科大學(xué)，基礎(chǔ)醫(yī)學(xué)院，職稱，學(xué)歷，碩博導(dǎo)

行政職務(wù)：無

社會(huì)職務(wù)：中國神經(jīng)科學(xué)離子通道與受體分會(huì)副主任委員

上海神經(jīng)科學(xué)學(xué)會(huì)常務(wù)理事

中國細(xì)胞生物學(xué)學(xué)會(huì)神經(jīng)細(xì)胞生物學(xué)分會(huì)委員

國際學(xué)術(shù)期刊《Brain Behavior and Immunity》編委

國際學(xué)術(shù)期刊《Frontiers in Pharmacology》編委

招生專業(yè)：人體解剖學(xué)與組織胚胎學(xué)

研究領(lǐng)域：膜受體調(diào)控與疾病研究

培養(yǎng)研究生情況：指導(dǎo)碩士生5人，畢業(yè)2人，在讀3人

電子郵件：liyong68@hotmail.com、liyong68@shsmu.edu.cn

個(gè)人簡介：

受教育經(jīng)歷：（從大學(xué)本科開始，按時(shí)間倒排序）

2000/09 – 2003/07，中國科技大學(xué)，神經(jīng)生物學(xué)與生物物理學(xué)系，博士

1996/09 – 1999/07，徐州醫(yī)科大學(xué)，生物化學(xué)與分子生物學(xué)系，碩士

研究工作經(jīng)歷（按時(shí)間倒排序）

2018/03 –至今，上海交通大學(xué)醫(yī)學(xué)院，生物化學(xué)與分子細(xì)胞生物學(xué)，特聘教授

2009/03 – 2017/12，上海交通大學(xué)醫(yī)學(xué)院，生物化學(xué)與分子細(xì)胞生物學(xué)，研究員

2006/07 – 2009/03，美國阿拉巴馬大學(xué)伯明翰分校，研究助理

2004/01 – 2006/06，美國阿拉巴馬大學(xué)伯明翰分校，博士后

2003/03 – 2003/12，美國麻省理工學(xué)院腦與認(rèn)知神經(jīng)科學(xué)系，博士后

主持或參加科研項(xiàng)目及人才計(jì)劃項(xiàng)目情況（按時(shí)間倒序排序）：

項(xiàng)目類別、批準(zhǔn)號(hào)、名稱、研究起止年月、獲資助金額、項(xiàng)目狀態(tài)（已結(jié)題或在研等）、主持或參加。

1.科技部2030重大項(xiàng)目，2021ZD0203100，感知覺與情緒相互作用的神經(jīng)環(huán)路機(jī)制、2021/12-2026/11、263萬元、在研、子課題參與人。

2.上海市市級(jí)科技重大專項(xiàng)，待更新，阿爾茨海默病發(fā)病機(jī)制及相關(guān)創(chuàng)新藥的研究、2021/06-2025/12、500萬元、在研、子課題負(fù)責(zé)人。

3.科技部國家重點(diǎn)研發(fā)計(jì)劃，2020YFA0803600，組織器官代謝可塑性與記憶的調(diào)控機(jī)制及其生理病理意義、2020/12-2025/11、140.84萬元、在研、子課題負(fù)責(zé)人。

4.國家自然基金面上項(xiàng)目，82071510，Cofilin SUMO/deSUMO動(dòng)態(tài)修飾調(diào)控機(jī)制及其在焦慮中的作用、2021/01-2024/12、55萬元、在研、課題負(fù)責(zé)人。

5.國家自然基金重點(diǎn)項(xiàng)目，31830031，SUMO/deSUM修飾在痛癢覺調(diào)控中的作用和機(jī)制、2019/01-2023/12、284萬元、已結(jié)題、課題負(fù)責(zé)人。

6.國家自然基金國際(地區(qū))合作與交流項(xiàng)目，31761163002，SENP3在自閉癥中的作用和機(jī)制、2018/01-2020/12、195萬元、已結(jié)題、課題負(fù)責(zé)人。

7.國家自然基金面上項(xiàng)目，31671053，TRPV1 SUMO/deSUMO修飾調(diào)控膜轉(zhuǎn)運(yùn)及其在痛覺調(diào)控中的作用、2017/01-2020/12、62萬元、已結(jié)題、課題負(fù)責(zé)人。

8.國家自然基金面上項(xiàng)目，31371064，SUMO/DeSUMO化修飾在抑制性受體膜轉(zhuǎn)運(yùn)中的作用、2014/01-2017/12、85萬元、已結(jié)題、課題負(fù)責(zé)人。

9.科技部國家重大科學(xué)研究計(jì)劃項(xiàng)目，2014CB910303，重要新型膜離子通道的生理和藥理功能、2014/01-2018/12、120萬元、已結(jié)題、子課題負(fù)責(zé)人。

10.國家自然基金面上項(xiàng)目，81171230，內(nèi)源性BDNF在Rett綜合癥中的作用研究、2012/01-2015/12、60萬元、已結(jié)題、主要責(zé)任人。

11.國家自然科學(xué)基金重大研究計(jì)劃/重點(diǎn)支持項(xiàng)，91132303，情感和記憶調(diào)控的抑制性神經(jīng)環(huán)路機(jī)制、2012/01-2015/12、100萬元、已結(jié)題、課題參與人。

12.上海市科委浦江人才項(xiàng)目，11PJ1406100，甘氨酸受體膜轉(zhuǎn)運(yùn)調(diào)節(jié)機(jī)制、    2011/01-2013/12、20萬元、已結(jié)題、課題負(fù)責(zé)人。

13.國家自然基金面上項(xiàng)目，30970937，14-3-3蛋白調(diào)控CaV2.2通道膜轉(zhuǎn)運(yùn)及其機(jī)制研究、2010/01-2012/12、35萬元、已結(jié)題、課題負(fù)責(zé)人。

14.科技部國家重大科學(xué)研究計(jì)劃子項(xiàng)目，2010CB912001，神經(jīng)元信息感受重要蛋白質(zhì)膜轉(zhuǎn)運(yùn)的結(jié)構(gòu)基礎(chǔ)、調(diào)控及功能研究、2010/01-2014/12、135萬元、已結(jié)題、子課題負(fù)責(zé)人。

15.上海市科委"創(chuàng)新行動(dòng)計(jì)劃"基礎(chǔ)研究重點(diǎn)項(xiàng)目，09JC1408700，14-3-3蛋白調(diào)控CaV2.2通道膜轉(zhuǎn)運(yùn)及其機(jī)制研究、2009/09-2011/08、30萬元、已結(jié)題、課題負(fù)責(zé)人。

代表性論著（按以下格式填寫）

1. Qiao Zhang, Weiji Weng, Xiaokun Gu, Jinhua Xiang, Yang Yang, Michael X Zhu, Weidong Gu*, Zhenzhou He*,Yong Li*. hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA. Cell Reports, 42(11):113401, 2023.

2. Weiji Weng, Xiaokun Gu, Yang Yang, Qiao Zhang, Qi Deng, Jie Zhou, Jinke Cheng, Michael X. Zhu, Junfeng Feng*, OuHuang*,Yong Li*. N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization. Nature Communications, 14(1):5688, 2023.

3. Yingwei Gao, Ruining Ma, Weiji Weng, Heng Zhang, Yingping Wang, Rongjun Guo, Xiaokun Gu, Yang Yang, Fan Yang, Aiwu Zhou, Jinke Cheng, Zhe-Yu Chen*, Michael X Zhu*, Yong Li*. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. Cell Reports, 39(11):110972, 2022.

4. Siman Gao, Xiangteng Zhao, Lin Hou, Ruining Ma, Jie Zhou, Michael X. Zhu, Si-Jian Pan,Yong Li. The interplay between SUMOylation and phosphorylation of PKCd facilitates oxidative stress-induced apoptosis. The FEBS Journal,  288(22):6447-6464, 2021.

5.Xiangteng Zhao, Bianbian Xia, Jinke Cheng, Michael X Zhu,Yong Li. PKC epsilon SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain. Cell Reports, 33(1):108191, 2020.

6. Huiqing Liu, Weiji Weng, Rongjun Guo, Jie Zhou, Jun Xue , Shan Zhong , Jinke Cheng, Michael X Zhu, Si-Jian Pan*,Yong Li *. Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting. Cell Death and Differentiation, 27(11):3146-3161, 2020.  

7. Dehua Huang, Huiqing Liu, Aoxue Zhu, Yi Zhou,Yong Li. Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior. Molecular Brain, 13(1):59, 2020.

8. Ruining Ma, Lina Ma, Weiji Weng, Yingping Wang, Huiqing Liu, Rongjun Guo, Yingwei Gao, Jun Tu, Tian-Le Xu, Jinke Cheng, Michael X Zhu, Aiwu Zhou*,Yong Li*. DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation. Science Advances, 6(13):eaaz0361, 2020.

9. Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X Zhu,Yong Li. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nature Communications, 9(1):1529, 2018. (highlighted in “Faculty of 1000”, 2018).

10. Xiaoling Li, Yan Wang, Aoxue Zhu, Jie Zhou,Yong Li. PKC SUMOylation inhibits the binding of 14-3-3τ to GluK2. Channels (Austin), 11(6):616-623, 2017.

11. Huijun Zhang, Yan Wang, Aoxue Zhu, Dehua Huang, Shining Deng, Jinke Cheng, Michael X Zhu,Yong Li. SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. Cell Death and Disease, 7, e2484, 2016.

12. Yan Wang, Yangbo Wang, Huijun Zhang, Yingwei Gao, Chao Huang, Aiwu Zhou, Yi Zhou,Yong Li. Sequential posttranslational modifications regulate PKC degradation. Molecular Biology of the Cell, 27:410-420, 2016.

13. Feng Liu, Qin Zhou, Jie Zhou, Hao Sun, Yan Wang, Xiuqun Zou, Lingling Feng, Zhaoyuan Hou, Aiwu Zhou, Yi Zhou,Yong Li. 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels. Journal of Biological Chemistry , 290(5):2689-2698, 2015.

14. Hao Sun, Li Lu, Yong Zuo, Yan Wang, Yingfu Jiao, Wei-Zheng Zeng, Chao Huang, Michael X Zhu, Gerald W Zamponi, Tong Zhou, Tian-Le Xu, Jinke Cheng,Yong Li. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nature Communications, 5:4980, 2014.

15. Changcheng Sun, Haifa Qiao, Qin Zhou, Yan Wang, Yuying Wu, Yi Zhou,Yong Li. Modulation of GluK2a Subunit-containing kainate receptors by 14-3-3 Proteins. Journal of Biological Chemistry, 288:24676-24690, 2013.

16. Chen Huang, Wei-Guang Li, Xiao-Bing Zhang, Li Wang, Tian-Le Xu, Dazheng Wu*,Yong Li. Alpha-asarone from Acorus gramineusalleviates epilepsy by modulating A-Type GABA receptors. Neuropharmacology, 65:1-11, 2013.

17. Li Wang, Wei-Guang Li, Chen Huang, Michael X Zhu, Tian-Le Xu, Da-Zheng Wu*,Yong Li*. Subunit-specific inhibition of glycinereceptors by curcumol. Journal of Pharmacology and Experimental Therapeutics, 343(2):371-9, 2012.

18.Yong Li, Xinqiu Liu, Yuying Wu, Zhe Xu, Hongqin Li, Leslie C Griffith, Yi Zhou. Intracellular regions of the Eag potassiumchannel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry, 286(2):1389-99, 2011.

19.Yong Li, Gaston Calfa, Takafumi Inoue, Michelle D Amaral, Lucas Pozzo-Miller. Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons, Journal of Neurophysiology, 103(5):2846-56, 2010.

20. Roujian Lu,Yong Li, Youwen Zhang, Yunjia Chen, Angela D Shields, Danny G Winder, Timothy Angelotti, Kai Jiao, Lee E Limbird, Yi Zhou, Qin Wang. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. Journal of Biological Chemistry, 284(19):13233-43, 2009.

21.Yong Li, Yuying Wu, Rui Li, Yi Zhou. The role of 14-3-3 dimerization in its modulation of the CaV2.2 Channel. Channels (Austin), 1(1):1-2, 2007.

22.Yong Li, Yuying Wu, Yi Zhou. Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins. Neuron, 51(6):755-71, 2006.

23.Yong Li, Long-Jun Wu, Pascal Legendre, Tian-Le Xu. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. Journal of Biological Chemistry, 278(40):38637-45, 2003.

24.Yong Li, Yan-Fang Li, Tian-Le Xu. Amiloride inhibition of glycinergic mIPSCs in mechanically dissociated rat spinal neurons. Neuroscience Letters, 349(1):17-20, 2003.

25.Yong Li, Tian-Le Xu. State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport, 13(2):223-6, 2002.

26. Lin Pei,Yong Li, Guangyi Zhang, Zhaochun Cui, Zhengmei Zhu. Mechanisms of regulation of tyrosine phosphorylation of NMDA receptor subunit 2B after cerebral ischemia/reperfusion. Acta Pharmacologica Sinica, 21(8):695-700, 2000.

27. Lin Pei,Yong Li,  Jingzhi Yan, Guangyi Zhang, Zhaochun Cui, Zhengmei Zhu. Changes and mechanisms of protein-tyrosine kinase and protein-tyrosine phosphatase activities after brain ischemia/reperfusionsubunit 2B after cerebral ischemia/reperfusion. Acta Pharmacologica Sinica, 21(8):715-20, 2000.