姓名：李勇
出生年月：1968年1月
基本情況：昆明醫科大學，基礎醫學院，職稱，學歷，碩博導
行政職務：無
社會職務：中國神經科學離子通道與受體分會副主任委員
上海神經科學學會常務理事
中國細胞生物學學會神經細胞生物學分會委員
國際學術期刊《Brain Behavior and Immunity》編委
國際學術期刊《Frontiers in Pharmacology》編委
招生專業：人體解剖學與組織胚胎學
研究領域：膜受體調控與疾病研究
培養研究生情況：指導碩士生5人，畢業2人，在讀3人
電子郵件：liyong68@hotmail.com、liyong68@shsmu.edu.cn
個人簡介：
受教育經歷：（從大學本科開始，按時間倒排序）
2000/09 – 2003/07，中國科技大學，神經生物學與生物物理學系，博士
1996/09 – 1999/07，徐州醫科大學，生物化學與分子生物學系，碩士
研究工作經歷（按時間倒排序）
2018/03 –至今，上海交通大學醫學院，生物化學與分子細胞生物學，特聘教授
2009/03 – 2017/12，上海交通大學醫學院，生物化學與分子細胞生物學，研究員
2006/07 – 2009/03，美國阿拉巴馬大學伯明翰分校，研究助理
2004/01 – 2006/06，美國阿拉巴馬大學伯明翰分校，博士后
2003/03 – 2003/12，美國麻省理工學院腦與認知神經科學系，博士后
主持或參加科研項目及人才計劃項目情況（按時間倒序排序）：
項目類別、批準號、名稱、研究起止年月、獲資助金額、項目狀態（已結題或在研等）、主持或參加。
1.科技部2030重大項目，2021ZD0203100，感知覺與情緒相互作用的神經環路機制、2021/12-2026/11、263萬元、在研、子課題參與人。
2.上海市市級科技重大專項，待更新，阿爾茨海默病發病機制及相關創新藥的研究、2021/06-2025/12、500萬元、在研、子課題負責人。
3.科技部國家重點研發計劃，2020YFA0803600，組織器官代謝可塑性與記憶的調控機制及其生理病理意義、2020/12-2025/11、140.84萬元、在研、子課題負責人。
4.國家自然科學基金面上項目，82071510，Cofilin SUMO/deSUMO動態修飾調控機制及其在焦慮中的作用、2021/01-2024/12、55萬元、在研、課題負責人。
5.國家自然科學基金重點項目，31830031，SUMO/deSUM修飾在痛癢覺調控中的作用和機制、2019/01-2023/12、284萬元、已結題、課題負責人。
6.國家自然科學基金國際(地區)合作與交流項目，31761163002，SENP3在孤獨癥中的作用和機制、2018/01-2020/12、195萬元、已結題、課題負責人。
7.國家自然科學基金面上項目，31671053，TRPV1 SUMO/deSUMO修飾調控膜轉運及其在痛覺調控中的作用、2017/01-2020/12、62萬元、已結題、課題負責人。
8.國家自然科學基金面上項目，31371064，SUMO/DeSUMO化修飾在抑制性受體膜轉運中的作用、2014/01-2017/12、85萬元、已結題、課題負責人。
9.科技部國家重大科學研究計劃項目，2014CB910303，重要新型膜離子通道的生理和藥理功能、2014/01-2018/12、120萬元、已結題、子課題負責人。
10.國家自然科學基金面上項目，81171230，內源性BDNF在Rett綜合癥中的作用研究、2012/01-2015/12、60萬元、已結題、主要責任人。
11.國家自然科學基金重大研究計劃/重點支持項，91132303，情感和記憶調控的抑制性神經環路機制、2012/01-2015/12、100萬元、已結題、課題參與人。
12.上海市科委浦江人才項目，11PJ1406100，甘氨酸受體膜轉運調節機制、 2011/01-2013/12、20萬元、已結題、課題負責人。
13.國家自然科學基金面上項目，30970937，14-3-3蛋白調控CaV2.2通道膜轉運及其機制研究、2010/01-2012/12、35萬元、已結題、課題負責人。
14.科技部國家重大科學研究計劃子項目，2010CB912001，神經元信息感受重要蛋白質膜轉運的結構基礎、調控及功能研究、2010/01-2014/12、135萬元、已結題、子課題負責人。
15.上海市科委"創新行動計劃"基礎研究重點項目，09JC1408700，14-3-3蛋白調控CaV2.2通道膜轉運及其機制研究、2009/09-2011/08、30萬元、已結題、課題負責人。
代表性論著（按以下格式填寫）
1. Qiao Zhang, Weiji Weng, Xiaokun Gu, Jinhua Xiang, Yang Yang, Michael X Zhu, Weidong Gu*, Zhenzhou He*,Yong Li*. hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA. Cell Reports, 42(11):113401, 2023.
2. Weiji Weng, Xiaokun Gu, Yang Yang, Qiao Zhang, Qi Deng, Jie Zhou, Jinke Cheng, Michael X. Zhu, Junfeng Feng*, OuHuang*,Yong Li*. N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization. Nature Communications, 14(1):5688, 2023.
3. Yingwei Gao, Ruining Ma, Weiji Weng, Heng Zhang, Yingping Wang, Rongjun Guo, Xiaokun Gu, Yang Yang, Fan Yang, Aiwu Zhou, Jinke Cheng, Zhe-Yu Chen*, Michael X Zhu*, Yong Li*. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. Cell Reports, 39(11):110972, 2022.
4. Siman Gao, Xiangteng Zhao, Lin Hou, Ruining Ma, Jie Zhou, Michael X. Zhu, Si-Jian Pan,Yong Li. The interplay between SUMOylation and phosphorylation of PKCd facilitates oxidative stress-induced apoptosis. The FEBS Journal, 288(22):6447-6464, 2021.
5.Xiangteng Zhao, Bianbian Xia, Jinke Cheng, Michael X Zhu,Yong Li. PKC epsilon SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain. Cell Reports, 33(1):108191, 2020.
6. Huiqing Liu, Weiji Weng, Rongjun Guo, Jie Zhou, Jun Xue , Shan Zhong , Jinke Cheng, Michael X Zhu, Si-Jian Pan*,Yong Li *. Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting. Cell Death and Differentiation, 27(11):3146-3161, 2020.
7. Dehua Huang, Huiqing Liu, Aoxue Zhu, Yi Zhou,Yong Li. Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior. Molecular Brain, 13(1):59, 2020.
8. Ruining Ma, Lina Ma, Weiji Weng, Yingping Wang, Huiqing Liu, Rongjun Guo, Yingwei Gao, Jun Tu, Tian-Le Xu, Jinke Cheng, Michael X Zhu, Aiwu Zhou*,Yong Li*. DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation. Science Advances, 6(13):eaaz0361, 2020.
9. Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X Zhu,Yong Li. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nature Communications, 9(1):1529, 2018. (highlighted in “Faculty of 1000”, 2018).
10. Xiaoling Li, Yan Wang, Aoxue Zhu, Jie Zhou,Yong Li. PKC SUMOylation inhibits the binding of 14-3-3τ to GluK2. Channels (Austin), 11(6):616-623, 2017.
11. Huijun Zhang, Yan Wang, Aoxue Zhu, Dehua Huang, Shining Deng, Jinke Cheng, Michael X Zhu,Yong Li. SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. Cell Death and Disease, 7, e2484, 2016.
12. Yan Wang, Yangbo Wang, Huijun Zhang, Yingwei Gao, Chao Huang, Aiwu Zhou, Yi Zhou,Yong Li. Sequential posttranslational modifications regulate PKC degradation. Molecular Biology of the Cell, 27:410-420, 2016.
13. Feng Liu, Qin Zhou, Jie Zhou, Hao Sun, Yan Wang, Xiuqun Zou, Lingling Feng, Zhaoyuan Hou, Aiwu Zhou, Yi Zhou,Yong Li. 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels. Journal of Biological Chemistry , 290(5):2689-2698, 2015.
14. Hao Sun, Li Lu, Yong Zuo, Yan Wang, Yingfu Jiao, Wei-Zheng Zeng, Chao Huang, Michael X Zhu, Gerald W Zamponi, Tong Zhou, Tian-Le Xu, Jinke Cheng,Yong Li. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nature Communications, 5:4980, 2014.
15. Changcheng Sun, Haifa Qiao, Qin Zhou, Yan Wang, Yuying Wu, Yi Zhou,Yong Li. Modulation of GluK2a Subunit-containing kainate receptors by 14-3-3 Proteins. Journal of Biological Chemistry, 288:24676-24690, 2013.
16. Chen Huang, Wei-Guang Li, Xiao-Bing Zhang, Li Wang, Tian-Le Xu, Dazheng Wu*,Yong Li. Alpha-asarone from Acorus gramineusalleviates epilepsy by modulating A-Type GABA receptors. Neuropharmacology, 65:1-11, 2013.
17. Li Wang, Wei-Guang Li, Chen Huang, Michael X Zhu, Tian-Le Xu, Da-Zheng Wu*,Yong Li*. Subunit-specific inhibition of glycinereceptors by curcumol. Journal of Pharmacology and Experimental Therapeutics, 343(2):371-9, 2012.
18.Yong Li, Xinqiu Liu, Yuying Wu, Zhe Xu, Hongqin Li, Leslie C Griffith, Yi Zhou. Intracellular regions of the Eag potassiumchannel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry, 286(2):1389-99, 2011.
19.Yong Li, Gaston Calfa, Takafumi Inoue, Michelle D Amaral, Lucas Pozzo-Miller. Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons, Journal of Neurophysiology, 103(5):2846-56, 2010.
20. Roujian Lu,Yong Li, Youwen Zhang, Yunjia Chen, Angela D Shields, Danny G Winder, Timothy Angelotti, Kai Jiao, Lee E Limbird, Yi Zhou, Qin Wang. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. Journal of Biological Chemistry, 284(19):13233-43, 2009.
21.Yong Li, Yuying Wu, Rui Li, Yi Zhou. The role of 14-3-3 dimerization in its modulation of the CaV2.2 Channel. Channels (Austin), 1(1):1-2, 2007.
22.Yong Li, Yuying Wu, Yi Zhou. Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins. Neuron, 51(6):755-71, 2006.
23.Yong Li, Long-Jun Wu, Pascal Legendre, Tian-Le Xu. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. Journal of Biological Chemistry, 278(40):38637-45, 2003.
24.Yong Li, Yan-Fang Li, Tian-Le Xu. Amiloride inhibition of glycinergic mIPSCs in mechanically dissociated rat spinal neurons. Neuroscience Letters, 349(1):17-20, 2003.
25.Yong Li, Tian-Le Xu. State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport, 13(2):223-6, 2002.
26. Lin Pei,Yong Li, Guangyi Zhang, Zhaochun Cui, Zhengmei Zhu. Mechanisms of regulation of tyrosine phosphorylation of NMDA receptor subunit 2B after cerebral ischemia/reperfusion. Acta Pharmacologica Sinica, 21(8):695-700, 2000.
27. Lin Pei,Yong Li, Jingzhi Yan, Guangyi Zhang, Zhaochun Cui, Zhengmei Zhu. Changes and mechanisms of protein-tyrosine kinase and protein-tyrosine phosphatase activities after brain ischemia/reperfusionsubunit 2B after cerebral ischemia/reperfusion. Acta Pharmacologica Sinica, 21(8):715-20, 2000.
