姓名:云宇
出生年月:1978.05
基本情況:昆明醫科大學,基礎醫學院,教授,博士,博導
行政職務:藥理學系主任
社會職務:無
招生專業:藥理學
研究領域:高尿酸血癥的防治
培養研究生情況:指導碩士生9人,畢業5人,在讀4人
電子郵件:yunyu_li@126.com
個人簡介:
受教育經歷:(按時間倒排序)
2006 /09–2010/07,昆明醫科大學,藥學院藥理系,博士
2003 /09–2006/07,昆明醫科大學,基礎醫學院藥理學系,碩士
1996 /09–2001/07,昆明醫科大學,臨床學院,學士
研究工作經歷(按時間倒排序)
2001 /09– 至今,昆明醫科大學,基礎醫學院藥理學系,教授
主持或參加科研項目及人才計劃項目情況:
1.云南省科技廳科學研究基金,202101AY070001-007,尿酸酶基因敲除大鼠腸道尿酸分布規律及其機制研究,2021.09-2024.10,40萬元,在研,主持
2.國家自然科學基金面上項目,81860162,尿酸酶基因敲除模型大鼠的研制,2019.01-2022.12,35萬元,在研,主持
3. 云南省教育廳科學研究基金,2018JS153,腸道尿酸的特征性分布及其機制研究,2018.05-2021.05,4萬元,已結題,主持
4. 云南省科技廳聯合基金,2014FZ006,從腸道毒素入侵途徑探討下肢、腹部受涼導致普通感冒的發病機制,2014.10-2017.09,10萬,已結題,主持
5. 云南省科技廳聯合基金,2012FB014,缺血后處理對大鼠腎臟再灌注損傷Nrf2/Keap1/ARE通路調節機制的研究,2012.10-2015.09, 10萬,已結題,主持
代表性論著(按以下格式填寫)
1. 期刊論文:
l Yu Y, Wan X, Li D, Qi Y, Li N, Luo G, Yin H, Wang L, Qin W, Li Y, Li L, Duan W. Dieting alleviates hyperuricemia and organ injuries in uricase-deficient rats via down-regulating cell cycle pathway. PeerJ. 2023;11:e15999.
l Yinfang Gao, Yun Yu, Wan Qin, Nan Fan, Yalin Qi, Huan Chen, Weigang Duan*. Uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia. PLoS One. 2022;17(3): e0264696
l Nan Fan,Yun Yu, Lvyu Li, Heng Xia, Xiangxian Dong, Yongkun Li, Huan Chen, Weigang Duan*. Uricase deficiency causes mild and multiple organ injuries in rats.PLoS One, 2021; 16(8):e0256594.
l Yun Yu, Nan Zhang, Xianxiang Dong,Nan Fan,Lei Wang,Yuhui Xu, Huan Chen,and Weigang Duan*. Uricase-deficient rat is generated with CRISPR/Cas9 technique,Peer J,8,:e8971 http://doi.org/10.7717/peerj.8971
l Dequan Liu,Yu Yun ,Dechun Yang, Xinyu Hu, Xianxiang Dong, Nan Zhang Hua Yin,Lumei Zhang, Weigang Duan*.what is the biological function of uric acid?An antioxidant for neural protection or a biomarker for cell death,Diseasemarker, 2019:4081962.
l 云宇,李月,楊榕,張路梅,董鮮翔,殷華,熊云霞,段為鋼.氨丁三醇在體外促尿酸溶解作用,華西藥學雜志,2018,33(1):037-041.
l Yu Yun , Hua Yin , Zhiyi Gao, Yue Li, Tao Gao, Jinlian Duan, Rong Yang, Xianxiang Dong, Lumei Zhang, Weigang Duan*, Intestinal tract is an important organ for lowering serum uric acid in rats,PLoS One, 2017; 12(12):e0190194.
l 云宇,侯肖霖,殷華,柯瑾,段為鋼*, 4種去大分子中藥注射劑的穩定性研究, 云南中醫學院學報,2016,39(04):20~25.
l Yu Yun, Tao Gao, Yue Li, Zhiyi Gao, Jinlian Duan, Hua Yin, Weigang Duan*, Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine,The Scientific World Journal,2016, 2016: 1~8
2. 會議論文:
l Yu Yun#,Yi Zhang,and Weigang Duan*, Mixed RNA duplexes , a new type of neucleic acid inhibit A549 cell line growing,Proceedings of the 2015 International Conference on, Food Hygiene, Agriculture and Animal Science, 2015, WuHan,P.R. China, 2015.11.18-11.22
l Yu Yun#, Yi Zhang, and Weigang Duan*, Benefits and Disadvantages of Assay Kits in Experimental Education, International Conference on Management Science, Education Technology, Arts, Social Science and Economics, 2015, Qingdao, P.R. China, 2015.11.21-11.25
3. 獎勵:云宇,王殿華,褚微微,武步強,朱振東,腎、肝和腸缺血-再灌注損傷及缺血后處理保護機制研究,云南省科技廳, 自然科學獎,三等獎,2012