一、個人簡介
博士,副教授,碩士生導師,昆明醫科大學百名中青年學術和技術骨干,現任法醫學院黨政辦公室主任、昆明醫科大學司法鑒定中心法醫物證鑒定室主任,主要從事法醫物證教學、科研和司法鑒定工作。為云南省高校優秀共產黨員,為昆明醫科大學法醫分子鑒定科技創新團隊、昆明醫科大學泛素化修飾與腫瘤免疫科技創新團隊骨干成員。國家司法鑒定人、云南省資質認定評審員、云南省司法鑒定協會法醫類專業委員會委員、云南省司法鑒定專家庫專家。主持完成省部級等科研項目10余項,以第一作者或通訊作者在國內外刊物公開發表學術論著34篇,其中SCI收錄論文19篇。獲云南省高校教師教學大賽二等獎1項、昆明醫科大學教學成果獎二等獎1項、昆明醫科大學首屆教師教學創新大賽一等獎1項、昆明醫科大學全英文課堂教學比賽二等獎1項。
二、主要研究方向
法醫群體遺傳結構分析、精神分裂癥及攻擊行為的遺傳機制研究。
三、近五年主要承擔科研項目
上海市法醫學重點實驗室 司法部司法鑒定重點實驗室,開放課題,KF202410,云南漢族人群73個常染色體STR基因座的遺傳多態性及法醫學應用研究, 2024-05至2026-04,5萬元,在研,主持。
云南省科技廳-昆明醫科大學聯合專項,面上項目,202301AY070001-232,SLC6A4基因表達與精神分裂癥的關聯性及高甲基化調控表達的機制研究,2023-06至2025-05,10萬元,在研,主持。
云南省科技廳,基礎研究計劃-面上項目,202101AT070347,RNA結合蛋白RALY調控CTRP1介導三陰性乳腺癌發生發展的機制研究,2022-06至 2025-05,10萬元,在研,主持。
云南省科技廳-昆明醫科大學聯合專項,青年博士項目,2018FE001(-131),NR3C1基因3’-UTR區域多態性與精神分裂癥的關聯性及功能研究,2018-06至2021-06,8萬元,在研,主持。
省部共建云南生物資源保護與利用國家重點實驗室,開放課題,2017KF002,TBC1D8B基因致癌調控研究,2017-06至2021-06,10萬元,在研,主持。
昆明醫科大學2022年教研教改課題,2022-JY-Y-022,法醫學專業學生科研創新能力的培養實踐探索,2022.8-2024.8,0.5萬元,在研,主持。
國家級大學生創新實驗計劃項目,2024CYD041,基于網絡藥理學、分子對接和實驗驗證揭示大麻二酚致人肝毒性病變的分子機制,2024-05至2026-04,2萬元,在研,指導教師。
省級大學生創新實驗計劃項目,2024CYD130,云南漢族人群GRIK3基因T928G多態性與精神分裂癥的關聯研究,2024-05至2026-04,1萬元,在研,指導教師。
國家級大學生創新實驗計劃項目,2023CXD031,云南漢族人群SLC6A4基因5-HTTLPR多態性精神分裂癥的關聯研究,2023-12至2025-12,2萬元,在研,指導教師。
省級大學生創新實驗計劃項目,2023CXD129,基于二代測序的Y-STR家系遺傳結構解析與法醫學應用研究,2024-05至2025-04,1萬元,在研,指導教師。
四、近五年代表性學術成果
Yumei Lu#, Lili Qing#, Liping Hu#, Wensa Yin, Xuanyu Chen, Zhiyong Wang, Tiantian Cheng, Jia Wang, Linlin Liu*, Shengjie Nie*. Hypomethylation and high expression of the TMTC1 gene in patients with schizophrenia. Asian Journal of Psychiatry. 2024.93:103922.(IF=9.5)
Hui Zhao#*, Linlin Liu#, Jian Sun#, Lian Jin#, HaiBing Xie#, JianBo Li, Hui Xu, DongDong Wu, XiaoLin Zhuang, MinSheng Peng, YaJun Guo, WeiZhu Qian, Newton O. Otecko, WeiJie Sun, LiangHu Qu, Jie He, ZhaoLi Chen, Rong Liu, CeShi Chen*, YaPing Zhang*. A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression. Science China-Life Sciences. 2023 Dec 15.(IF=9.1)
Xuanyu Chen#, Lili Qing#, Tiantian Zou#, Jia Wang, Wensa Yin, Zhiyong Wang, Tiantian Cheng, Yumei Lu, Liping Hu*, Linlin Liu*, Shengjie Nie*. An analysis of POMC gene methylation and expression in patients with schizophrenia. International Journal of Developmental Neuroscience. 2024.1-9. (IF=1.8)
Yanxia Peng#, Yihang Wang#, Linlin Liu#, Genmeng Yang, Dongxian Zhang, Shijun Hong*, Lihua Li*. The effects of ketamine and methamphetamine on neurotransmitters, glutamate receptors, and conditioned place preference in rat. Leg Med (Tokyo). 2023;65:102328.(IF=1.5)
Linlin Liu#, Jiahui Yuan#, Lei Miao, Renwu Huang, Xiufeng Zhang, Shengjie Nie, Liping Hu. Genetic polymorphisms of 16 X-STR loci analyzed in the Han population of Yunnan Province, Southwest China. Legal medicine. 2022;54:101974.(IF=2.017)
Linlin Liu#, Jinyong Yao#, Yangzhi Huang, Lei Gao, Jiameng Dai, Xiaokun Yuan, Xiufeng Zhang*, Shengjie Nie, Liping Hu*. Genetic polymorphisms of 16 X-STR loci in the Hani population from Southwest China. Forensic Sciences Research. 2022;7 (2), 196-201.(IF=1.2)
Linlin Liu#, Yi Hu#, Yumei Lu, Liping Hu*, Changqing Gao*, Shengjie Nie*. Sex-dependent DNA hypermethylation of SLC6A4 in patients with schizophrenia. Neuroscience Letters. 2022;769:136394. (IF=3.197)
Wenzhu Zhang#, Linlin Liu#, Shengdi Zhao, Liang Chen, Yuxian Wei, Wenlin Chen*, Fei Ge*. Research progress on RNA-binding proteins in breast cancer. Oncology letters. 2022;23: 121.(IF=3.111)
Yanli Du#, Linlin Liu#, Yong Liu, Kun Wang, Hongmei Shi, Yang He, Yingxiang Long, Dawei Sun, Hao Wu, Xiannan Zi, Xuzheng Li, Wei Huang, Ru Zhang, Changrong Ge. Ovary transcriptome profiling in high- and low-yielding Chinese Chahua laying chickens. Czech Journal Of Animal Science. 2022;67(8):327-338.(IF=1.349)
Xiufeng Zhang#, Xiaokun Yuan#, Yangzhi Huang, Jinyong Yao, Jian Zhang, Jiameng Dai, Linlin Liu*, Shengjie Nie*, Liping Hu*. Forensic genetic polymorphisms of 16 X-STR loci in the Yunnan Miao population and their relationship to other Chinese groups. Legal medicine. 2021;53:101961. (IF=2.017)
Linlin Liu#, Xiaopei Yang#, Fei Zhao#, Changqing Gao, Ning Zhang, Jianjun Bao, Kuan Li, Xulan Zhang, Xiaoxiao Lu, Ye Ruan*, Shurong Zhong*. Hypermethylation of the OPRM1 and ALDH2 promoter regions in Chinese Han males with alcohol use disorder in Yunnan Province. American Journal of Drug and Alcohol Abuse. 2021;47(6):694-703.(IF=3.912)
Linlin Liu#, Jiajue Li#, Lili Qing, Ming Yan, Gen Xiong, Xinqing Lian, Liping Hu*, Shengjie Nie*. Glucocorticoid Receptor Gene (NR3C1) Is Hypermethylated in Adult Males With Aggressive Behaviour. International Journal of Legal Medicine. 2021;135(1):43-51. (IF=2.686)
Linlin Liu#, Jian Wu#, Lili Qing , Jiajue Li, Hao Yang, Aicen Ji, Ming Yan, Liping Hu*, Shengjie Nie*. DNA Methylation Analysis of the NR3C1 Gene in Patients With Schizophrenia. Journal of Molecular Neuroscience, 2020;70(8):1177-1185. (IF=3.444)
Yanli Du#, Linlin Liu#, Yang He, Tengfei Dou, Jingjun Jia*, Changrong Ge*. Endocrine and Genetic Factors Affecting Egg Laying Performance in Chickens: A Review. British Poultry Science. 2020;1-12.(IF=2.095)
LiliQing#, LinlinLiu#, LiZhou, FanZhang, ChangqingGao*, LipingHu*, ShengjieNie*. Sex-dependent association of mineralocorticoid receptor gene (NR3C2) DNA methylation and schizophrenia. Psychiatry Research. 2020;292:113318.(IF=3.222)
程甜甜,尹文卅,王佳,盧玉梅,陳炫羽,聶勝潔,劉林林*. TMTC1基因多態性與精神分裂癥的關聯性.昆明醫科大學學報,2023,(10):161-167.
五、聯系郵箱: liull0818@126.com