• 法醫學院博士研究生導師——陳勇彬



    一、個人簡介

    陳勇彬,博士,研究員,博導,博士后合作導師。中國科學院昆明動物研究所PI。國家高層次人才特殊支持計劃科技創新領軍人才,科技部創新人才推進計劃中青年科技領軍人才,國家優青,國家海外高層次人才引進計劃青年項目獲得者,中國科學院海外高層次人才,云南省有突出貢獻優秀專業技術人才,云南省高端科技人才,云南省海外高層次人才,云南省高層次人才培養支持計劃產業技術領軍人才,云嶺學者項目支持。主持國家基金項目7項,中國科學院項目2項,省部級項目8項。作為唯一/共同通訊作者發表SCI論文50余篇,總IF大于530。參編著作3部。獲云南省青年科技獎,云南省科學技術進步獎特等獎、一等獎、二等獎各1項,授權國家發明專利8項。

    二、主要研究方向

    1)法醫病理生理學;(2)腫瘤新生物標志物挖掘及抗腫瘤新藥篩選。

    三、近五年主要承擔科研項目

    1)國家自然科學基金重點項目,82230099,GLT8D1抑制鐵死亡促進腫瘤免疫逃逸的功能與機制研究,2023.01-2027.12,261萬,在研,主持。

    2)國家自然科學基金-云南聯合基金,U2102206,GLT8D1通過CD133/Wnt/β-catenin軸影響膠質瘤干細胞活性和腫瘤進展的功能與機制研究,2022.01-2025.12,233萬,在研,主持。

    3)云南省基礎研究計劃-重大項目,202401BC070013,極端環境進化適應與實體瘤異質性形成的共性研究,2024.03-2027.02,300萬,在研,主持。

    4)“興滇英才支持計劃”云嶺學者項目支持,腫瘤低氧微環境時空變化與腫瘤異質性,2024.01-2026.12,500萬,在研,主持。

    5)云南省重大科技專項計劃生物醫藥專項,202202AA100007,治療膠質瘤靶向藥物樂卡地平臨床前研究,2022.01-2024.12,300萬,在研,主持。

    6)國家自然科學基金面上項目,81772996,凝縮蛋白家族成員NCAPH影響結直腸癌發生發展的功能與機制研究,2018.01-2021.12,55萬,結題,主持。

    7)中國科學院科研儀器設備研制項目,YJKYYQ20190048,生物組織光層析大視場顯微成像系統,2020.01-2021.12,300萬,結題,主持。

    8)云南省應用基礎研究重點項目,202001AS070037,高原動物趨同進化適應候選基因的篩選及功能機制研究,2020.06-2023.05,50萬,結題,主持。

    四、近五年代表性學術成果

    1)Qiushuo Shen#, Yanfei Han#, Kai Wu#, Yaomei He, Xiulin Jiang, Peishen Liu, Cuifeng Xia, Qiuxia Xiong,Rui liu, Qianming Chen, Yong Zhang, Song Zhao*, Cuiping Yang*,Yongbin Chen*.MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling .Signal Transduction and Targeted Therapy. 2022 May 4;7(1):147.(IF= 39.3)

    2)Kun Liu#,Liping Jiang#, Yulin Shi,Baiyang Liu,Yaomei He, Qiushuo Shen,Xiulin Jiang,Zhi Nie,Jun Pu,Cuiping Yang,Yongbin Chen*.Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation.Cell Death and Differentiation.2022 Sep;29(9):1834-1849.(IF= 12.4)

    3)Yaomei He#, Xiulin Jiang#, Lincan Duan#, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang*,Yongbin Chen*.LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.Molecular Cancer.2021 Dec 2;20(1):156(IF= 41.444)

    4)Qiuxia Xiong#, Liping Jiang#, Kun Liu#, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan*, Cuiping Yang*, Yongbin Chen *.miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer.Signal Transduction and Targeted Therapy.2021 Jul 7;6(1):252(IF= 38.12)

    5)Xiulin Jiang#, Baiyang Liu#, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang?, Yongbin Chen?.The role of m6A modification in the biological functions and diseases.Signal Transduction and Targeted Therapy.2021 Feb 21;6(1):74(IF- 38.12)

    6)Peifang Xu#, Liping Jiang#, Yang Yang#, Mengge Wu, Baiyang Liu, Yulin Shi, Qiushuo Shen, Xiulin Jiang, Yaomei He, Dating Cheng, Qiuxia Xiong, Zuozhang Yang, Lincan Duan, Jie Lin, Song Zhao, Peng Shi, Cuiping Yang*, Yongbin Chen*.PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.Theranostics.2020 Feb 19;10(8):3767-3778(IF= 11.556)

    7)Yulin Shi#, Songqing Fan#, Mengge Wu#, Zhixiang Zuo,  Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu,  Lin Zeng, Yongchun Zhou, Yunchao Huang,  Zuozhang Yang,  Jumin Zhou,Jing Gao, Hu Zhou, Shuhua Xu,  Hongbin Ji, Peng Shi, Dongdong Wu*, Cuiping Yang*, Yongbin Chen*.YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.Nature Communications. 2019 Oct 25;10(1):4892.(IF= 12.121)

    8)Xiulin Jiang#, Yong Zhang#, Yixiao Yuan#, Zhixian Jin#, Haoqing Zhai, Baiyang Liu, Yao Li, Chun Zhang, Min Chen, Yulin Shi, Dongming Yan*, Jun Pu*, Yongbin Chen*, Cuiping Yang*.LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression.International Journal of Biological Sciences. 2023 Mar 5;19(6):1681-1697(IF= 10.75)

    9)Dongming Xu#, Cuiping Yang#, Qiushuo Shen#, Shengkai Pan#,Zhen Liu#, Tongzuo Zhang#, Xin Zhou, Menglong Lei, Peng Chen,Hui Yang, Tao Zhang,Yuanting Guo, Xiangjiang Zhan*, Yongbin Chen*,  Peng Shi*.A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau.Cell Research.2021 Sep;31(9):1032-1035(IF= 46.351)

    10)Dongdong Wu*#, Cuiping Yang#, Mingshan Wang #, Kunzhe Dong #, Dawei Yan #, Ziqian Hao#, Songqing Fan, Shuzhou Chu, Qiushuo Shen, Liping Jiang , Yan Li , Lin Zeng, Hequn Liu, Haibing Xie, Yunfei Ma, Xiaoyan Kong , Shuli Yang , Xinxing Dong , Ali Esmailizadeh, David M Irwin, Xiao Xiao, Ming Li, Yang Dong, Wen Wang, Peng Shi, Haipeng Li, Yuehui Ma*, Xiao Gou*, Yongbin Chen*, Yaping Zhang*.Convergent genomic signatures of high-altitude adaptation among domestic mammals.National Science Review. 2020 Jun;7(6):952-963(IF= 17.275)

    五、聯系郵箱: ybchen@mail.kiz.ac.cn






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