一、個人簡介
嚴慧，博士，研究員，碩士生導師。司法鑒定科學研究院法醫毒物法化研究室副主任/研究員，主持和參與國家和省部級科研項目10余項，主持和參與制定毒物毒品鑒定技術國家標準、行業標準20余項，在國內外有影響力的專業期刊上發表論文80余篇,參與撰寫《法醫毒物學手冊》等多部專著，被《法醫學雜志》《Forensic science research》等多家雜志聘為專家審稿人、專業編輯，曾獲司法部司法為民好榜樣稱號，上海市科技進步一等獎、三等獎。
二、主要研究方向
從事法醫毒物學教學培訓、科學研究及司法鑒定工作，主要研究方向：（1）體內毒物及代謝物分析；（2）新型毒品體內外代謝研究；（3）毒物中毒機制的代謝組學研究。
三、近五年主要承擔的科研項目
（1）國家重點研發計劃子課題，新精神活性物質篩選數據庫構建及預警系統組建研究，2022.10-2025.9,主持
（2）上海市自然科學基金項目，新型毒品5-MeO-DiPT的體內代謝和作用機制研究，2019.7-2022.6，主持
（3）上海市人才發展基金，2020.1-2021.12，主持
四、近五年代表性成果
[1]Jiao-Jiao Ji, Jiaman Lin, Xin Wang, Hang Chen, Qiran Sun, Duoqi Xu, Ping Xiang,Junling Dun, Hui Yan*, Min Shen*.Estimation of the time of zolpidem intake and differentiation between consumption and external contamination using MALDI-MSI for investigations on single hair samples.Journal of Pharmaceutical and Biomedical Analysis.2024,248: 116272.（IF=3.1）
[2]Yiling Tang, Linhao Xu, Junbo Zhao, Ping Xiang, Hui Yan*.Metabolism of dipentylone in zebrafish and human liver microsomes determined by liquid chromatography–high resolution mass spectrometry.Journal of Pharmaceutical and Biomedical Analysis. 2023,236:115710. （IF=3.1）
[3]Mobing Chen, Wei Liu, Ping Xiang, Linhao Xu, Yiling Tang, Ran Kong, Shuo Yang, Hui Yan*,Bin Di.Development of an LC-MS/MS method for the determination of multiple mycotoxins in human Urine.Food Additives & Contaminants: Part A.2023,40(7):917-927. （IF=2.3）
[4]Linhao Xu,Xinze Liu,Zixuan Song,Ping Xiang,Taijun Hang,Hui Yan*.In vitro and in vivo metabolism of 3-Methoxyeticyclidine inhuman liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography–high-resolution mass spectrometry.Drug Testing and Analysis. 2023;1–8.DOI: 10.1002/dta.3488. （IF=2.6）
[5]Caixia Guo#,Hui Yan#, Wei Liu,Ping Xiang,Bin Di,Min Shen.Liquid chromatography with tandem mass spectrometric method for determination of 425 drugs and poisons in dried blood spots and application to forensic cases.Forensic Toxicology,2023, https://doi.org/10.1007/s11419-023-00659-9. （IF=2.8）
[6]Xinze Liu, Wei Liu, Ping Xiang, Taijun Hang, Yan Shi, Linna Yue, and Hui Yan*. Metabolism of ADB-4en-PINACA in Zebrafish and Rat Liver Microsomes Determined by Liquid Chromatography–High Resolution Mass Spectrometry.Journal of Analytical Chemistry, 2022,77(8):1036–1046.（IF=1.0）
[7] Mobing Chen, Xinze Liu, Shuo Yang, Zhuonan Chen, Bin Di, Wei Liu*, Hui Yan*.HPLC–MS/MS method for the simultaneous determination of aflatoxins in blood: toxicokinetics of aflatoxin B 1 and aflatoxin M 1 in rats. Journal of Analytical Science and Technology.2022,13:27-37.（IF=2.5）
[8]Kai Zhang#, Hui Yan#, Ruina Liu, Ping Xiang, Kaifei Deng, Ji Zhang, Ya Tuo, Zhenyuan Wan*, Ping Huang*. Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted metabolomics. Journal of Chromatography B, doi:10.1016/j.jchromb.2021.122638（IF=2.8）
[9]Yue Linna, Xiang Ping, Shen Baohua, Xu Duoqi, Song Fenyun, Yan Hui*. Metabolism of 4F-MDMB-BICA in zebrafish by liquid chromatography-high resolution mass spectrometry. Drug Testing and Analysis.2021,13:1223-1229.（IF=2.6）
[10]Zhang Kai#, Yan Hui#, Liu Ruina, Xiang Ping, Zhang Ji, Deng Kaifei,Huang Ping*, Wang Zhenyuan*.The Use of Gas Chromatography Coupled with High-Resolution Mass Spectrometry-Based Untargeted Metabolomics to Discover Metabolic Changes and Help in the Determination of Complex Causes of Death: A Preliminary Study.ACS Omega,2021,6(3):2100-2109.（IF=3.7）
五、聯系郵箱: yanh@ssfjd.cn
