昆明醫科大學類器官研究院院長
復旦大學生命科學學院、附屬中山醫院雙聘教授
遺傳工程國家重點實驗室“類器官研究中心”主任PI
國家“優秀青年基金”獲得者
國家重點研發計劃“干細胞及轉化研究”項目負責人（青年）
“東方學者”特聘教授、上海市青年拔尖人才
通訊地址：上海市復旦大學生命科學學院A501室 郵編：200438
電話：18612372986 電子郵箱：zhaobing@kmmu.edu.cn
教育、工作經歷
研究員 復旦大學 2017.4---至今 博士后 辛辛那提兒童醫學院醫學中心 2015.11---2017.3 博士后 清華-北大生命科學聯合中心 2013.7---2015.9 生物學博士 清華大學 2008.9---2013.6 理學學士 中國農業大學 2005.9---2008.6
科研方向與主要成績
利用小鼠遺傳、類器官模型，研究成體干細胞命運決定機制，并發展類器官培育新策略。以第一/通訊作者身份于國際權威期刊Cell Research、Nature Communications、 Advanced Science、Protein & Cell、Developmental Cell等發表系列性研究論文，為再生生物學發展提供重要基礎。代表性研究成果獲Nature News專訪報道、Nature官網主頁高亮，獲國際權威綜述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度評價。
致力于推進類器官技術標準化，開拓醫藥應用新場景。2018年創立復旦大學類器官中心；主編或參編“十四五”國家重點研發、國家博士后創新創業、上海市重點、廣東 省重點等多個類器官重點專項項目指南；牽頭制定類器官培養行業標準規范；主筆類器官臨床應用中國專家共識；主辦年度類器官高峰論壇；促進藥審藥評鼓勵意見出臺。多維度打造類器官產業轉化和醫藥應用行業新生態。
主持在研項目
項目名稱
經費（萬元)
起止年月
項目性質及來源
擔任角色
染色質重構在肝臟細胞命運決定中的作用及其機制
547
2018.7---2022.12
科技部國家重點研發計劃
項目負責人
信號轉導與成體干細胞命運決定
120
2021.1---2023.12
國家自然科學基金優秀青年科學基金項目
項目負責人
Znhit1基因在Lgr5小腸干細胞命運決定中的作用及其機制
60
2018.1---2021.12
國家自然科學基金面上項目
項目負責人
Emc3在腸上皮穩態維持中的作用及其機制
57
2020.1---2023.12
國家自然科學基金面上項目
項目負責人
內胚層類器官構建及其形成機制研究
400
2021.10---2026.9
上海市科委基礎研究特區計劃
項目負責人
獎勵與榮譽
復星醫藥獎教金（一等）
復旦大學 2020 2021 “東方學者”特聘教授 上海市教委 2019 上海市青年拔尖人才 上海市委組織部，人社局 2018 上海市青年科技啟明星（A類） 上海市教委 2018 生命科學院院長獎 復旦大學 2018 AMGEN Postdoctoral Award AMGEN 2015 北京市優博 北京市教委 2013 其它工作
第八屆國務院學位辦生物學、生物工程學科評議組副秘書長
中國細胞生物學學會細胞治療研究與應用分會委員
中國生物醫學工程學會類器官與器官芯片分會委員
中國微生物學會第十二屆理事會委員（細胞因子與干擾素專業委員會）
《Cell Transplantation》、《遺傳》雜志編委
《Cell Regeneration》干細胞信號調控專刊客座主編
《Organs-on-a-Chip》類器官專刊客座主編
復旦大學生物學博士后流動站專家委員
代表性學術論文
1. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J*, Xu S* and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (工程技術1區Top), 9:2202505. (*corresponding author)
2. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X*, Wang X* and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (工程技術1區Top), 9:2105568.
3. Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B* and Chen X*. (2022) Single-cell transcriptomic atlas highlights origin and pathological process of human endometrioid endometrial carcinoma. Nature Communications (綜合1區Top), 13:6300.
4. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1區Top), 57:901–913. (Cover Story)
5. Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H*, Zhao B* and Lin X*. (2022) Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry, 298:102490.
6. Meng F, Shen C, Yang L, Ni C, Huang J, Lin K, Cao Z, Xu S, Cui W, Wang X, Zhou B, Xiong C, Wang J and Zhao B*. (2022) Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regeneration, 11:39.
7. Chen J, Zhang J, Yang L and Zhao B*. (2022) Facile suspension culture protocol of the liver biliary organoids. Bio-Design Engineering and Manufacture, doi.org/10.1007/s42242-022-00213-3.
8. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J* and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1區Top), 13:683-688.
9. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (醫學1區Top), 14:873-886. (Cover Story and 2021 Editor’s Choice)
10. Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B*, Zheng X* and Liu T*. (2021) Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis. Frontiers in Immunology, 12:784975.
11. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X* and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (醫學1區Top), 34:3348-3358.
12. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J*, Zhang R* and Lin X*. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1區Top), 11:771-775. (Highlighted by Nature)
13. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12: 618-629.
14. Zhao B*, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X*. (2019) Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nature Communications (綜合1區Top), 10:1071.
15. Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X*, Ling C* and Zhao B*. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry, 294:14096-14104.
16. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG. (2017) BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes. Nature Communications (綜合1區Top), 8:13824.
17. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG*. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications (綜合1區Top), 6:7166.
18. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X. (2015) Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology (工程技術1區Top), 10:465-71.
19. Cui HK#, Zhao B#, Li Y, Guo Y, Hu H, Liu L* and Chen YG*. (2013) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research (生物1區Top), 23:581-584. (# co-first author)
20. Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG*. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Research (生物1區Top), 22:1467-1478.
Review Articles:
1. Li Y, Gao X, Ni C, Zhao B* and Cheng X*. (2023) The application of patient-derived organoid in the research of lung cancer. Cellular Oncology (醫學1區Top), doi.org/10.1007/s13402-023-00771-3.
2. Wei J, Zhang W and Zhao B*. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration, 12:17.
3. Liang J, Li X, Dong Y and Zhao B*. (2022) Modeling Human Organ Development and Diseases With Fetal Tissue-Derived Organoids. Cell Transplantation, 31:1–15.
4. Lv T, Meng F, Yu M, Huang H, Lin X and Zhao B*. (2021) Defense of COVID‐19 by Human Organoids. Phenomics,1:113–128.
5. Zhao B and Chen YG*. (2014) Regulation of TGF-?? Signal Transduction. Scientifica, 2014:874065.
